Bryan G Fry Selected Research

Venoms

9/2022	Untangling interactions between Bitis vipers and their prey using coagulotoxicity against diverse vertebrate plasmas.
3/2022	Efficacy and Limitations of Chemically Diverse Small-Molecule Enzyme-Inhibitors against the Synergistic Coagulotoxic Activities of Bitis Viper Venoms.
1/2022	Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacy.
12/2021	A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic Properties.
6/2021	Pharmacological Characterisation of Pseudocerastes and Eristicophis Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of Fibrinogenolysis.
4/2021	Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors.
1/2021	The Dragon's Paralysing Spell: Evidence of Sodium and Calcium Ion Channel Binding Neurotoxins in Helodermatid and Varanid Lizard Venoms.
1/2021	Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans.
1/2021	A Clot Twist: Extreme Variation in Coagulotoxicity Mechanisms in Mexican Neotropical Rattlesnake Venoms.
1/2021	ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations.

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Bryan G Fry Research Topics

Disease

13	Snake Bites (Snake Bite) 03/2022 - 01/2013
9	Bites and Stings (Sting) 10/2020 - 12/2013
8	Paralysis (Palsy) 01/2021 - 02/2016
4	Pain (Aches) 01/2021 - 11/2018
3	Melanoma (Melanoma, Malignant) 10/2022 - 01/2021
3	Hemorrhage 01/2022 - 02/2006
3	Wounds and Injuries (Trauma) 01/2020 - 06/2009
3	Myotoxicity 08/2003 - 01/2003
2	Bluetongue 09/2022 - 01/2021
2	Stroke (Strokes) 01/2022 - 10/2020
2	Neoplasms (Cancer) 06/2021 - 01/2021
2	Muscle Spasticity (Spastic) 01/2021 - 10/2016
2	Human Bites (Bite, Human) 08/2020 - 11/2019
2	Shock 01/2018 - 06/2009
1	Hypotension (Low Blood Pressure) 01/2022
1	Tachycardia (Tachyarrhythmias) 01/2021
1	Skin Neoplasms (Skin Cancer) 01/2021
1	Asphyxia (Suffocation) 10/2020
1	Thrombosis (Thrombus) 01/2019
1	Hypertension (High Blood Pressure) 05/2018
1	Disseminated Intravascular Coagulation 10/2017
1	Anaphylaxis (Anaphylactic Shock) 09/2013
1	Hyperalgesia 04/2006
1	Contracture 04/2006
1	Unconsciousness (Loss of Consciousness) 02/2006

Drug/Important Bio-Agent (IBA)

35	VenomsIBA 09/2022 - 01/2003
14	Antivenins (Antivenoms)IBA 03/2022 - 01/2003
5	Peptides (Polypeptides)IBA 10/2022 - 12/2013
3	AnticoagulantsIBA 01/2022 - 01/2019
3	Snake Venoms (Snake Venom)IBA 06/2021 - 08/2003
3	Pharmaceutical PreparationsIBA 02/2021 - 06/2015
3	Fibrinogen (Factor I)FDA Link 10/2020 - 01/2019
2	SodiumIBA 01/2021 - 10/2020
2	Proteins (Proteins, Gene)FDA Link 03/2015 - 04/2006
1	Adenosine Triphosphate (ATP)IBA 10/2022
1	TachykininsIBA 10/2022
1	Kallikreins (Kallikrein)IBA 03/2022
1	EnzymesIBA 03/2022
1	Natriuretic PeptidesIBA 01/2022
1	Viper Venoms (Viper Venom)IBA 06/2021
1	varespladibIBA 02/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2021
1	MitogensIBA 01/2021
1	LY3214996IBA 01/2021
1	Calcium Channels (Calcium Channel)IBA 01/2021
1	Sirolimus (Rapamycin)FDA Link 01/2021
1	Mitogen-Activated Protein KinasesIBA 01/2021
1	CecropinsIBA 01/2021
1	Blood Coagulation Factors (Coagulation Factor)IBA 10/2020
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 10/2020
1	Spider Venoms (Venom, Spider)IBA 01/2020
1	CalciumIBA 11/2019
1	clotting enzymeIBA 11/2019
1	Prothrombin (Factor II)IBA 11/2019
1	Thrombin FDA Link 11/2019
1	IceIBA 01/2018
1	Sodium Channel AgonistsIBA 10/2016
1	Sodium Channels (Sodium Channel)IBA 10/2016
1	Three Finger ToxinsIBA 10/2016
1	Scorpion Venoms (Scorpion Venom)IBA 12/2013
1	Elapid Venoms (Cobra Venom)IBA 04/2006
1	Tubocurarine (Tubocurarine Chloride)FDA Link 04/2006
1	4-bromophenacyl bromideIBA 01/2003
1	NeurotoxinsIBA 01/2003

Therapy/Procedure

3	First Aid (Aids, First) 03/2022 - 01/2018
2	Therapeutics 10/2022 - 01/2021
1	Immunotherapy 10/2022
1	Canes (Cane) 09/2022
1	Surgical Amputation (Amputations) 05/2018
1	Premedication 01/2018
1	Tourniquets 01/2018
1	Fasciotomy 01/2018
1	Transcutaneous Electric Nerve Stimulation (TENS) 01/2018